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In a randomised control trial, lanifibranor treatment reduced steatohepatitis activity and improved fibrosis.[124] Liver enzymes decreased and lipid biomarkers, inflammation and fibrosis were ameliorated.[124] PPAR agonists also have benefits in the regulation of lipid metabolism, which means that not only can they be used for patients with NAFLD, but they can also be used to reduce ASCVD risk.[121] Conclusion NAFLD is a public health problem affecting up to one-third of the world's adult population and is considered a multisystemic disease associated with extrahepatic alterations
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