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Altered NO metabolism and NO scavenging by transfusion of damaged RBCs was proposed to play a role in cardiovascular effects of older blood, but alteration of other noncanonical functions of RBCs, including redox dysregulation and mechanical properties, may be involved in these effects

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According to the applicant, the DETOUR System received Breakthrough Device designation from FDA on September 2, 2020 for percutaneous revascularization of symptomatic femoropopliteal lesions 200mm to 460mm with a chronic total occlusion 100mm to 425mm, and/or moderate-to-severe calcification, and/or in-stent-restenosis in patients with severe peripheral arterial disease