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In yet another embodiment, the linker-drug compound is of formula (Ib-1), R 2 and R 2′ are independently N, CH or CMe, and R 5 is NH 2 , OH, or R 3 and R 5 are optionally being joined by one or more bonds to form an optionally substituted carbocycle or heterocycle, preferably an optionally substituted 5- or 6-membered carbocycle or heterocycle