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3 The molecular mechanisms of ferroptosis 3.1 Iron metabolism and ferroptosis Iron homeostasis is maintained by a sophisticated network of absorption, transport, storage, and efflux ( Figure 2 ) ( Figure 2 Ferroportin 1 (Fpn), the sole known mammalian non-heme iron exporter, is widely distributed in neurons, astrocytes, oligodendrocytes, and brain microvascular endothelial cells and is crucial for murine embryonic development, forebrain patterning, and neural tube closure ( 3.2 Lipid peroxidation in ferroptosis A defining hallmark of ferroptosis involves the accumulation of lipid peroxidation, primarily driven by oxidative damage to polyunsaturated fatty acid-containing phospholipids (PUFA-PLs) ( in vitro and in vivo (HeLa cell line and mouse heterotopic tumor model) research identifies protein kinase C βII (PKCβII) as a crucial molecular sensor of lipid peroxidation

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However, earlier compounds faced pharmacological limitations