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For instance, targeting hepatocyte growth factor (HGF)-MET or IGF-1/IGF-1R signaling pathways—both critical for maintaining DTP states mediated through tumor-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs)—has shown promise in preclinical models (Yi et al., 2018)

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LT2 corrected the F/B ratio imbalance in the Model group by lowering the number of Firmicutes and increasing the number of Bacteroidetes