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Activation of TLR3 receptors in microglia causes increased release of IL-1β and TNF-α, which increases SERT expression in astrocytes and, therefore, 5-HT reuptake and its degradation to the metabolite 5-HIAA, thus reducing extracellular 5-HT levels
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A full series of nanomaterials, including liposomes, micelles, nanofibers, polymeric nanoparticles, and inorganic nanoparticles have been investigated to target the brain
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