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FB1 increases oxidative DNA damage, as measured by increased DNA strand breaks and malondialdehyde adducts in rat liver and kidney [111]

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Figure 1 3.1 Couplings between cytokines, NOX, NO, Ca i 2+ and HIF-1α From the point of view of control theory, it is not easy to design a system that, when exposed to a variety of pathogens, excites itself to levels high enough to fight the pathogen, but not so high as to exceed the threshold of self-destruction