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however, this association still requires further validation by prospective studies
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Disrupting the σ1R in cancer cells with an antagonist such as IPAG (1-(4-iodophenyl)-3-(2-adamantyl)guanidine) or rimcazole results in a large influx of [Ca 2+ ] into the cytosol, that can be reversed or prevented by σ1R knockdown or a σ1R agonists such as pentazocine, SKF10047 or PRE084 [6, 14, 75]
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