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used trypsin digestion to show that only a central domain of a lysine-rich histone H1 from calf thymus (residues 37–120) is in a folded conformation, whereas N- and C-terminal regions (residues 1–36 and 121–213, respectively) are very accessible in chromatin and therefore likely not in a compact, folded conformation ( Grzelczak et al

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Surgeries - Surgeries on the gastrointestinal system, such as gastric bypass (Roux-en-Y bypass surgery) and bowel resections, can eliminate the surface through which B vitamins are absorbed (13)