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Eventually, at high glucose levels, OS induction through regulating the protein kinase C (PKC), glycolysis, hexosamine, polyols pathway, and advanced glycation end products (AGE)

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Excess production of ROS correlates with the degree of airway hyperresponsiveness as quantified by methacholine challenge.22–24 Asthma attacks and experimental antigen challenges are both associated with immediate formation of , being high at the sites of antigen challenge that persists throughout the late asthmatic phase.22 The main nitrogen species produced in the lung is NO