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Cattle or bacterially derived hyaluronidases have also been used as a "spreading agent" to enhance the activity of chemotherapeutics and/or the accessibility of tumors to chemotherapeutics ( Schuller et al., 1991, Proc
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Moreover, these commensal bacteria can enhance host resistance to bacterial pneumonia by upregulating IL-17A expression and promoting signaling pathways for granulocyte-macrophage colony-stimulating factor (GM-CSF) in lung epithelial cells (52)
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