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For example, homozygous and heterozygous carriers of CYP2C9 gene variant alleles with reduced or no enzyme activity such as deletions would then require lower phenytoin doses to maintain therapeutic levels and to avoid an increased risk of toxicity with high drug doses for that patient prescribed for this anti-seizure drug 2,17

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GSSG sensitized hepatocytes to TNFα-mediated cytotoxicity via the induction of IKK-β glutathionylation and subsequent NF-κB suppression NF-κB activation plays a critical role in protecting hepatocytes from TNFα-mediated cytotoxicity