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Ng, Monash University / Metabolic Pharmaceuticals (Australia) How AOD 9604 Works: Two Complementary Lipolytic Mechanisms The Heffernan 2001 paper “The Effects of Human GH and Its Lipolytic Fragment (AOD 9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and β3-AR Knock-Out Mice” (Endocrinology, 142(12):5182-5189) established the mechanistic framework that subsequent research has confirmed and extended
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Following treatment medium was replaced and cell viability was assessed after 16 h ( Determination of Caspase 3 Activity Cells were plated on black, clear-bottomed collagen-coated 96-well plates at the density of 2 × 10 4 per well in 0.1 mL DMEM
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