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doi: 10.1016/0024-3205(96)00066-5 435 PereiraGGilliesHChandaSCorbettMVernonSDMilaniTet al

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Objectives Understand the physiologic functions of bile as a route for excretion and in aiding in the digestion and absorption of dietary lipids Understand how bile acids are formed from cholesterol, how they are modified during gut passage, and their role in driving bile secretion Describe the mechanisms that regulate the rate of conversion of cholesterol into bile acids Describe the major biliary lipids and how they are transported into the canaliculus Describe how the composition of bile is modified as the bile moves through the biliary ductules Define the cellular transport mechanisms that render bile alkaline Understand the consequences of a failure to secrete bile, and conditions that cause this problem Basic Principles of Biliary Excretion and Secretion The liver fulfills its excretory function by producing bile, a lipid-rich solution designed to promote the elimination of hydrophobic solutes