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Other indicators include a family history of pernicious anaemia or other autoimmune conditions (such as type 1 diabetes mellitus, Hashimoto’s thyroiditis, or Grave’s disease), or if the patient is taking metformin, proton pump inhibitors (PPIs), H2 antagonists or has a history of nitrous oxide misuse​[15]​

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This counter-screen strategy facilitates the exclusion of S mutants that are locally misfolded or have an expression defect