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Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy | Nature Nanotechnology

The consequences of the cardiovascular disease-related reductions in CBF include accelerated reduction in frontal, parietal, and temporal grey matter volumes (Moroni et al., 2018), cognitive deficits (Jiang et al., 2023), and increased risk of ADRD (Iturria-Medina et al., 2016), particularly in regions vulnerable to early pathology (entorhinal cortex, hippocampus, inferior parietal cortex, inferior temporal cortex) (Mattsson et al., 2014)

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In conclusion, these findings indicate that H 2 S may directly S-sulfhydrated Stat3 at Cys259 and then inhibited Stat3/CAS signaling to upregulate elastin level, resulting in the attenuation of vascular calcification