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Galectin-3 is an oncogenic protein that is involved in numerous processes, including cell growth, differentiation and adhesion, RNA splicing, apoptosis, neoplastic transformation, and metastasis, as well as being the guardian of the tumor microenvironment, suppressing immune surveillance by killing T-cells and interfering with NK cell function [106,107,108]
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• Finally, and possibly most importantly, astrocytes and microglia are unique among all cellular compartments in their flexible response to stress , which includes the formation of “stress memories”: Following pro-inflammatory stimulation glia remain in a reactive state and become hyperresponsive to subsequent stimulation because primed neuroglia respond at a different threshold than homeostatic neuroglia
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