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Introduction Multiple myeloma (MM) is the second most common hematological malignancy with significant heterogeneity, characterized by the accumulation of malignant plasma cells in the bone marrow that in the majority of cases secrete large amounts of monoclonal immunoglobulin paraproteins ( The intestinal microbiota plays a key role in many aspects of human physiological processes including nutrient metabolites uptake, immune regulation and response, reaction to infection ( Here, we discuss the role of gut microbiota in the host immune response, summarize the gastrointestinal microbiota profile of MM patients and discuss the potential mechanisms of gut microbial alterations in myeloma progression

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