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Vitamin C is a water-soluble vitamin and is also considered one of the most important antioxidants, acting at the level of extracellular fluids [224,225]

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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome