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acetyl l carnitine fasting L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study За проблемою_Розширені пори
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Journal of Clinical Endocrinology & Metabolism, 76: 819-823 Rennie (2003), Claims for the anabolic effects of growth hormone: a case of the Emperor’s new clothes
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recent data have shown that this effect involves prolactin produced locally by these tissues, indicating that the autocrine loop of action of this hormone may be a new therapeutic target Dopamine agonists, the classical drugs used to decrease prolactin production and release from the pituitary, do not affect production of prolactin in nonpituitary tissues Prolactin-receptor antagonists are engineered prolactin mutants designed to bind but not activate this receptor, with the aim of preventing the actions of endogenous prolactin by competing for receptor binding We have recently developed a new generation of human prolactin mutants that have no residual agonistic activity: in contrast to first-generation antagonists, these new compounds behave as pure antagonists Potential indications for this novel class of compounds involve breast and prostate tumors, as well as prolactin-secreting pituitary tumors that are resistant to dopamine-agonist treatment This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF
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