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The in vitro PhALC assay or the cell-based NanoBRET target engagement assay monitors only JNK1 specific effects under clean or more competitive conditions, respectively, while the two p-c-Jun assay reports on overall JNK inhibition in the used cell line
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added a double bind, placebo-controlled RCT of 72 patients with a mean follow-up of 92 weeks (54 - 157 weeks) to the latter’s meta-analysis which yielded similar results
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