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Notably, the ferroptosis inhibitor Ferrostatin-1 exacerbated CGA’s toxicity, while the inducer Erastin attenuated it (Supplementary Figure S2C), suggesting that the profound iron deficiency we describe disrupts fundamental metabolism in a manner distinct from, and prior to, the execution of classical ferroptosis—a pathway CGA has been shown to inhibit in other contexts via Nrf2/GPX4 activation (Yang et al., 2025)
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